Diagnostic value of anti-Mullerian hormone in adolescent girls with polycystic ovary syndrome

Background. Scientific debate continues on the diagnostic criteria for polycystic ovary syndrome in adolescents (PCOS). In these cause special problems due to fact that characteristics of normal puberty often coincide with signs and symptoms PCOS. There is a need develop PCOS adolescents, which could be used addition those proposed. A possible additional criterion may level anti-Mullerian hormone (AMH). The purpose study assess levels blood adolescent girls syndrome. Materials methods. clinical-anamnestic laboratory 27 (12–18 years) was conducted. comparison group consisted 25 same age without gynecological disorders. Determination AMG performed venous serum (Gen II ELISA, Beckman Coulter). Results. anamnesis analyzed: intrauterine hypoxia occurred almost half pathological course postnatal period observed 25.9%, infectious index 4.6, hypertensive-hydrocephalic found 23.8%, minimal cerebral dysfunction 28.5%, autonomic disorders— 47.6%, most surveyed had average body weight height, inverted disharmonious sexual development. common were: hypomenstrual (86.9%), dermopathy (82.6%) hirsutism (60.8%). mean 3.67±1.0 ng/ml (in 4.8±0.9 3.1±0.7 ng/ml, p<0.05). Adolescent form highest levels— 6.4 [4.8; 6.9] pg/ml, p<0.01, indicate probable value concentration. Conclusions. suspected should have complete set tests determine as an marker, especially absence clinical manifestations hyperandrogenemia.